Substrate: Telomeric repeat binding factor 1 (Telomeric repeat binding factor 1 (TTAGGG repeat binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1))
Seq-ID: P54274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14930   TINF2_HUMAN
MINT-16746   PINX1_HUMAN
MINT-17741   MARE1_HUMAN
MINT-17759   NDKA_HUMAN
MINT-62074   SMAD9_HUMAN
MINT-2831362   ORC2_HUMAN
MINT-6178188   STAG1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
protein homodimerization activity,
DNA bending activity,
telomeric DNA binding,
telomerase inhibitor activity,
microtubule binding,
caspase activator activity,
double-stranded telomeric DNA binding		 spindle,
nuclear telomere cap complex,
cytoplasm,
chromosome, telomeric region,
nucleoplasm,
nucleus		 negative regulation of telomere maintenance via semi-conservative replication,
cell division,
positive regulation of mitotic cell cycle,
activation of caspase activity,
regulation of transcription,
positive regulation of microtubule polymerization,
telomere maintenance via telomerase,
telomere maintenance via telomere shortening,
negative regulation of telomere maintenance via telomerase,
mitosis,
positive regulation of mitosis,
mitotic cell cycle spindle assembly checkpoint,
protein homooligomerization,
induction of apoptosis,
age-dependent telomere shortening,
G2/M transition of mitotic cell cycle,
negative regulation of telomerase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 11 MAEDVSSAAPSPRRCADGRDA - 17081983
HTP
0.14
 - -
0.73
 --
S 219 PFKSKLLMIISQKDTFHSFFQ ATM 11375976
LTP
0.12
 MOD_PIKK_1
 - TRF
0.10
 3BQO 70.49%
S 434 WRTMKKLKLISSDSED      - 18669648
HTP
0.00
 - -
0.49
 --
S 435 RTMKKLKLISSDSED       - 18669648
HTP
0.07
 - -
0.49
 --
S 437 MKKLKLISSDSED         - 18669648
HTP
0.00
 - -
0.42
 --

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